Lunesta: the Newest Prescription Sleeping Pill Lunesta became available in U.S. pharmacies in March 2005. It is the only sleeping pill approved by the FDA for longterm use. Clinical trials of most sleeping pills are only conducted for 2 to 4 weeks. Lunesta was studied for nightly use for 6-months. Call us today (858) 623-3266 to see if Lunesta is right for you.